Impact of Acupressure on Stress Hormones and Physiological Markers

Abstract

Stress is a physiological and psychological response to internal or external challenges, characterized by activation of the hypothalamic–pituitary–adrenal (HPA) axis and the autonomic nervous system. Persistent stress can elevate circulating cortisol, increase catecholamine release, raise blood pressure and heart rate, and disrupt immune and metabolic function. While pharmacological and behavioral therapies are commonly used to manage stress-related conditions, complementary approaches such as acupressure have gained increasing attention for their potential regulatory effects on stress hormones and physiological parameters. Acupressure is a non-invasive technique involving the application of manual pressure to specific acupoints associated with neuromodulatory and autonomic regulation. This study examines the impact of acupressure on stress-related biomarkers, including cortisol, adrenocorticotropic hormone (ACTH), heart rate variability (HRV), blood pressure, and salivary alpha-amylase. Evidence from clinical and experimental studies suggests that acupressure may reduce cortisol levels, enhance parasympathetic nervous system activity, stabilize cardiovascular parameters, and promote overall physiological relaxation.